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  • 产品名称：Anti-ASAH1 antibody (140-389) (STJ28610)

  • 产品型号：STJ28610
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ASAH1 antibody (140-389) (STJ28610)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ASAH1 (140-389) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ASAH1
Gene ID: 427
Uniprot ID: ASAH1_HUMAN
Immunogen Region: 140-389
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 140-389 of human ASAH1 (NP_001120977.1).
Immunogen Sequence: IVAEDKKGHLIHGRNMDFGV FLGWNINNDTWVITEQLKPL TVNLDFQRNNKTVFKASSFA GYVGMLTGFKPGLFSLTLNE RFSINGGYLGILEWILGKKD VMWIGFLTRTVLENSTSYEE AKNLLTKTKILAPAYFILGG NQSGEGCVITRDRKESLDVY ELDAKQGRWYVVQTNYDRWK HPFFLDDRRTPAKMCLNRTS QENISFETMYDVLSTKPVLN KLTVYTTLIDVTKGQFETY
Tissue Specificity Broadly expressed with higher expression in heart.
Post Translational Modifications N-glycosylated. Proteolytically cleaved into two chains alpha and beta that remain associated via a disulfide bond. Cleavage gives rise to a conformation change that activates the enzyme. The same catalytic Cys residue mediates the autoproteolytic cleavage and subsequent hydrolysis of lipid substrates. The beta chain may undergo an additional C-terminal processing.
Function Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Has a higher catalytic efficiency towards C12-ceramides versus other ceramides. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used. Has also an N-acylethanolamine hydrolase activity. By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes. Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis. By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis. Isoform 2: May directly regulate steroidogenesis by binding the nuclear receptor NR5A1 and negatively regulating its transcriptional activity.
Protein Name Acid Ceramidase
Ac
Acdase
Acid Cdase
Acylsphingosine Deacylase
N-Acylethanolamine Hydrolase Asah1
N-Acylsphingosine Amidohydrolase
Putative 32 Kda Heart Protein
Php32 Cleaved Into - Acid Ceramidase Subunit Alpha - Acid Ceramidase Subunit Beta
Database Links Reactome: R-HSA-1660662
Reactome: R-HSA-6798695
Cellular Localisation Lysosome
Secreted
Secretion Is Extremely Low And Localization To Lysosomes Is Mannose-6-Phosphate Receptor-Dependent
Isoform 2: Nucleus
Cytoplasm
A Localization To The Nucleus And The Cytoplasm Has Also Been Reported For Asah1
Most Probably For Isoforms Devoid Of A Signal Peptide
Alternative Antibody Names Anti-Acid Ceramidase antibody
Anti-Ac antibody
Anti-Acdase antibody
Anti-Acid Cdase antibody
Anti-Acylsphingosine Deacylase antibody
Anti-N-Acylethanolamine Hydrolase Asah1 antibody
Anti-N-Acylsphingosine Amidohydrolase antibody
Anti-Putative 32 Kda Heart Protein antibody
Anti-Php32 Cleaved Into - Acid Ceramidase Subunit Alpha - Acid Ceramidase Subunit Beta antibody
Anti-ASAH1 antibody
Anti-ASAH antibody
Anti-HSD-33 antibody
Anti-HSD33 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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