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  • 产品名称：Human COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2) Sandwich ELISA Kit Ready-To-Use (STJE0014449)

  • 产品型号：STJE0014449
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human COPS2 (COP9 Constitutive Photomorphogenic Homolog Subunit 2) Sandwich ELISA Kit Ready-To-Use (STJE0014449)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.065ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This COPS2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: COPS2
Gene ID: 9318
Uniprot ID: CSN2_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylated by CK2 and PKD kinases.
Function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Protein Name Cop9 Signalosome Complex Subunit 2
Sgn2
Signalosome Subunit 2
Alien Homolog
Jab1-Containing Signalosome Subunit 2
Thyroid Receptor-Interacting Protein 15
Tr-Interacting Protein 15
Trip-15
Database Links Reactome: R-HSA-5696394
Reactome: R-HSA-6781823
Reactome: R-HSA-8856825
Reactome: R-HSA-8951664
Reactome: R-HSA-9013422
Cellular Localisation Cytoplasm
Nucleus
Alternative ELISA Names Cop9 Signalosome Complex Subunit 2 ELISA kit
Sgn2 ELISA kit
Signalosome Subunit 2 ELISA kit
Alien Homolog ELISA kit
Jab1-Containing Signalosome Subunit 2 ELISA kit
Thyroid Receptor-Interacting Protein 15 ELISA kit
Tr-Interacting Protein 15 ELISA kit
Trip-15 ELISA kit
COPS2 ELISA kit
CSN2 ELISA kit
TRIP15 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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