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  • 产品名称：Mouse Stem Cell Factor protein (Recombinant) (STJP000479)

  • 产品型号：STJP000479
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse Stem Cell Factor protein (Recombinant) (STJP000479)
详情介绍：
Host: Insect cells
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse Stem Cell Factor-protein was developed from insect cells. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered solution in mM Tris, % trehalose, pH7.5.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: Can be stored in working aliquots at°C-°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/µg (1EU/µg). NA
Immunoreactivity: The ED (50) was determined by the dose-dependent stimulation of theproliferation of human TF-1 cells is x units/mg. NA
Gene Symbol: Kitlg
Gene ID: 17311
Uniprot ID: SCF_MOUSE
Immunogen Region: Mature chain
Immunogen: Optimized DNA sequence encoding Mouse SCF mature chain was expressed in Insect cells. NA
Immunogen Sequence: MKKTQTWIIT CIYLQLLLFN PLVKTKEICG NPVTDNVKDI TKLVANLPND YMITLNYVAG MDVLPSHCWL RDMVIQLSLS LTTLLDKFSN ISEGLSNYSI IDKLGKIVDD LVLCMEENAP KNIKESPKRP ETRSFTPEEF FSIFNRSIDA FKDFMVASDT SDCVLSSTLG PEKDSRVSVT KPFMLPPVA A SSLRNDSSSS NRKAAKAPED SGLQWTAMAL PALISLV
Tissue Specificity Expressed in the cochlea.
Post Translational Modifications A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain.
Function Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Protein Name Kit Ligand
Hematopoietic Growth Factor Kl
Mast Cell Growth Factor
Mgf
Steel Factor
Stem Cell Factor
Scf
C-Kit Ligand Cleaved Into - Soluble Kit Ligand
Skitlg
Database Links Reactome: R-MMU-1257604
Reactome: -MMU-1433557
Reactome: -MMU-1433559
Reactome: -MMU-5673001
Reactome: -MMU-6811558
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Cytoplasm
Cytoplasm
Cytoskeleton
Cell Membrane
Cell Projection
Lamellipodium
Filopodium
Soluble Kit Ligand: Secreted
Alternative Protein Names Kit Ligand protein
Hematopoietic Growth Factor Kl protein
Mast Cell Growth Factor protein
Mgf protein
Steel Factor protein
Stem Cell Factor protein
Scf protein
C-Kit Ligand Cleaved Into - Soluble Kit Ligand protein
Skitlg protein
Kitlg protein
Kitl protein
Mgf protein
Sl protein
Slf protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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