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  • 产品名称：TESK1 Blocking Peptide for STJ506188 peptide (STJ505887)

  • 产品型号：STJ505887-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
TESK1 Blocking Peptide for STJ506188 peptide (STJ505887)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: TESK1 Blocking Peptide for STJ506188 is synthetically produced from the 200-250 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TESK1
Gene ID: 7016
Uniprot ID: TESK1_HUMAN
Immunogen Region: 200-250
Specificity: This blocking peptide is recommended for use in combination with TESK1 antibody, STJ506188
Immunogen: Synthetic peptide corresponding to amino acids within region 200-250 on rat 5-hydroxytrptamine receptor 1A protein.
Post Translational Modifications Autophosphorylated on serine and tyrosine residues.
Function Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity. Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1. Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin. Suppresses ciliogenesis via multiple pathways.phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1. Probably plays a central role at and after the meiotic phase of spermatogenesis.
Peptide Name Dual Specificity Testis-Specific Protein Kinase 1
Testicular Protein Kinase 1
Database Links Reactome: R-HSA-446388
Cellular Localisation Cytoplasm
Perinuclear Region
Cytoskeleton
Microtubule Organizing Center
Centrosome
Cell Projection
Lamellipodium
Colocalizes With Spry4 In Vesicular Spots In The Cytoplasm
Localized To F-Actin-Rich Lamellipodia At The Cell Periphery Following Fibronectin-Mediated Cell Adhesion Of Schwann Cells
Alternative Peptide Names Dual Specificity Testis-Specific Protein Kinase 1 protein
Testicular Protein Kinase 1 protein
TESK1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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