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  • 产品名称：Human EPHA1 (Ephrin type-A receptor 1) CLIA Kit (STJC0000497)

  • 产品型号：STJC0000497
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human EPHA1 (Ephrin type-A receptor 1) CLIA Kit (STJC0000497)
详情介绍：
Applications: CLIA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Sensitivity: 37.5pg/mL
Detection Limit: 62.5~4000pg/mL
Short Description: This human EPHA1 kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.
Storage Instruction: If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
Assay Time: 3.5h
Detection: Chemiluminescence
Gene Symbol: EPHA1
Gene ID: 2041
Uniprot ID: EPHA1_HUMAN
Specificity: This kit recognizes Human EPHA1 in samples. No significant cross-reactivity or interference between Human EPHA1 and analogues was observed.
Sample Type: Serum, plasma and other biological fluids
Tissue Specificity Overexpressed in several carcinomas.
Post Translational Modifications Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1. Ubiquitinated.
Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Protein Name Ephrin Type-A Receptor 1
Hepha1
Eph Tyrosine Kinase
Eph Tyrosine Kinase 1
Erythropoietin-Producing Hepatoma Receptor
Tyrosine-Protein Kinase Receptor Eph
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-2892247
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative CLIA Names Ephrin Type-A Receptor 1 CLIA kit
Hepha1 CLIA kit
Eph Tyrosine Kinase CLIA kit
Eph Tyrosine Kinase 1 CLIA kit
Erythropoietin-Producing Hepatoma Receptor CLIA kit
Tyrosine-Protein Kinase Receptor Eph CLIA kit
EPHA1 CLIA kit
EPH CLIA kit
EPHT CLIA kit
EPHT1 CLIA kit
Specificity This kit recognizes Human EPHA1 in samples. No significant cross-reactivity or interference between Human EPHA1 and analogues was observed.
Reproducibility Both intra-CV and inter-CV are

Information sourced from Uniprot.org


Item Specifications Storage
Micro CLIA Plate (Dismountable) 96T: 8 wells ×12 strips strips -20℃, 6 months
Reference Standard 96T: 2 vials 48T: 1 vial -20℃, 6 months
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL 60 μL -20℃, 6 months
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL 60 μL -20℃ (Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL 2-8°C, 6 months
HRP Conjugate Diluent 1 vial, 14 mL 2-8°C, 6 months
Concentrated Wash Buffer (25×) 1 vial, 30 mL 2-8°C, 6 months
Substrate Reagent A 1 vial, 5 mL 2-8℃ (Protect from light)
Substrate Reagent B 1 vial, 5 mL 2-8℃ (Protect from light)
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 95-108 101
EDTA plasma(n=8) 96-112 102
Cell culture media(n=8) 98-110 103

Intra-assay Precision Intra-assay Precision Intra-assay Precision Inter-assay Precision Inter-assay Precision Inter-assay Precision
Sample 1.00 2.00 3.00 1.00 2.00 3.00
n 20.00 20.00 20.00 20.00 20.00 20.00
Mean (pg/mL) 183.06 424.08 1717.20 189.39 390.42 1573.46
Standard deviation 19.57 34.60 122.44 17.94 31.94 165.37
CV (%) 10.69 8.16 7.13 9.47 8.18 10.51
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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