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  • 产品名称：Human F11 (Coagulation factor XI) CLIA Kit (STJC0000397)

  • 产品型号：STJC0000397
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human F11 (Coagulation factor XI) CLIA Kit (STJC0000397)
详情介绍：
Applications: CLIA
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Sensitivity: 37.5pg/mL
Detection Limit: 62.5~4000pg/mL
Short Description: This human F11 kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes.
Storage Instruction: If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual.
Assay Time: 3.5h
Detection: Chemiluminescence
Gene Symbol: F11
Gene ID: 2160
Uniprot ID: FA11_HUMAN
Specificity: This kit recognizes Human F11 in samples. No significant cross-reactivity or interference between Human F11 and analogues was observed.
Sample Type: Serum, plasma and other biological fluids
Tissue Specificity Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.
Post Translational Modifications N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite. Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
Function Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Protein Name Coagulation Factor Xi
Fxi
Plasma Thromboplastin Antecedent
Pta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain
Database Links Reactome: R-HSA-140837
Reactome: R-HSA-9673221
Cellular Localisation Secreted
Alternative CLIA Names Coagulation Factor Xi CLIA kit
Fxi CLIA kit
Plasma Thromboplastin Antecedent CLIA kit
Pta Cleaved Into - Coagulation Factor Xia Heavy Chain - Coagulation Factor Xia Light Chain CLIA kit
F11 CLIA kit
Specificity This kit recognizes Human F11 in samples. No significant cross-reactivity or interference between Human F11 and analogues was observed.
Reproducibility Both intra-CV and inter-CV are

Information sourced from Uniprot.org


Item Specifications Storage
Micro CLIA Plate (Dismountable) 96T: 8 wells ×12 strips strips -20℃, 6 months
Reference Standard 96T: 2 vials 48T: 1 vial -20℃, 6 months
Concentrated Biotinylated Detection Ab (100×) 96T: 1 vial, 120 μL 60 μL -20℃, 6 months
Concentrated HRP Conjugate (100×) 96T: 1 vial, 120 μL 60 μL -20℃ (Protect from light), 6 months
Reference Standard & Sample Diluent 1 vial, 20 mL 2-8°C, 6 months
Biotinylated Detection Ab Diluent 1 vial, 14 mL 2-8°C, 6 months
HRP Conjugate Diluent 1 vial, 14 mL 2-8°C, 6 months
Concentrated Wash Buffer (25×) 1 vial, 30 mL 2-8°C, 6 months
Substrate Reagent A 1 vial, 5 mL 2-8℃ (Protect from light)
Substrate Reagent B 1 vial, 5 mL 2-8℃ (Protect from light)
Plate Sealer 5 pieces
Manual 1 copy
Certificate of Analysis 1 copy

Sample Type Range (%) Average Recovery (%)
Serum(n=8) 84-97 90
EDTA plasma(n=8) 93-107 98
Cell culture media(n=8) 87-99 93

Intra-assay Precision Intra-assay Precision Intra-assay Precision Inter-assay Precision Inter-assay Precision Inter-assay Precision
Sample 1.00 2.00 3.00 1.00 2.00 3.00
n 20.00 20.00 20.00 20.00 20.00 20.00
Mean (pg/mL) 201.15 543.25 1689.62 187.99 562.95 1616.64
Standard deviation 24.64 59.76 179.10 19.95 59.56 123.67
CV (%) 12.25 11.00 10.60 10.61 10.58 7.65
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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