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  • 产品名称：Anti-BICD2 antibody (440-620) (STJ112330)

  • 产品型号：STJ112330
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BICD2 antibody (440-620) (STJ112330)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-BICD2 (440-620) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BICD2
Gene ID: 23299
Uniprot ID: BICD2_HUMAN
Immunogen Region: 440-620
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 440-620 of human BICD2 (NP_001003800.1).
Immunogen Sequence: HVAVAEAGELREQLKALRST HEAREAQHAEEKGRYEAEGQ ALTEKVSLLEKASRQDRELL ARLEKELKKVSDVAGETQGS LSVAQDELVTFSEELANLYH HVCMCNNETPNRVMLDYYRE GQGGAGRTSPGGRTSPEARG RRSPILLPKGLLAPEAGRAD GGTGDSSPSPGSSLPSPLSD P
Tissue Specificity Ubiquitous.
Post Translational Modifications Phosphorylated by NEK9 in vitro.
Function Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport via its interaction with RAB6A and recruitment of the dynein-dynactin motor complex. Contributes to nuclear and centrosomal positioning prior to mitotic entry through regulation of both dynein and kinesin-1. During G2 phase of the cell cycle, associates with RANBP2 at the nuclear pores and recruits dynein and dynactin to the nuclear envelope to ensure proper positioning of the nucleus relative to centrosomes prior to the onset of mitosis.
Protein Name Protein Bicaudal D Homolog 2
Bic-D 2
Database Links Reactome: R-HSA-6811436
Cellular Localisation Golgi Apparatus
Cytoplasm
Cytoskeleton
Nucleus Envelope
Nucleus
Nuclear Pore Complex
In Interphase Cells Mainly Localizes To The Golgi Complex And Colocalizes With Dynactin At Microtubule Plus Ends
Localizes To The Nuclear Envelope And Cytoplasmic Stacks Of Nuclear Pore Complex Known As Annulate Lamellae In A Ranbp2-Dependent Manner During G2 Phase Of The Cell Cycle
Alternative Antibody Names Anti-Protein Bicaudal D Homolog 2 antibody
Anti-Bic-D 2 antibody
Anti-BICD2 antibody
Anti-KIAA0699 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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