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  • 产品名称：Anti-ARIH1/HHARI antibody (C-Term) (STJ70308)

  • 产品型号：STJ70308-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ARIH1/HHARI antibody (C-Term) (STJ70308)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human/Mouse/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-ARIH1/HHARI (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-Recommended for use at 0.2-1µg/ml
IHC-5µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ARIH1
Gene ID: 25820
Uniprot ID: ARI1_HUMAN
Immunogen Region: C-Term
Accession Number: NP_005735.2
Immunogen Sequence: HEGYEKDLWEYIED
Function E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes. Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear. According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest. According to another report EIF4E2 ubiquitination leads to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2. In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, nuclear subcellular localization and nuclear morphology.
Protein Name E3 Ubiquitin-Protein Ligase Arih1
H7-Ap2
Hhari
Monocyte Protein 6
Mop-6
Protein Ariadne-1 Homolog
Ari-1
Ubch7-Binding Protein
Ubcm4-Interacting Protein
Ubiquitin-Conjugating Enzyme E2-Binding Protein 1
Database Links Reactome: R-HSA-1169408
Cellular Localisation Cytoplasm
Nucleus
Cajal Body
Mainly Cytoplasmic
Present In Lewy Body
Alternative Antibody Names Anti-E3 Ubiquitin-Protein Ligase Arih1 antibody
Anti-H7-Ap2 antibody
Anti-Hhari antibody
Anti-Monocyte Protein 6 antibody
Anti-Mop-6 antibody
Anti-Protein Ariadne-1 Homolog antibody
Anti-Ari-1 antibody
Anti-Ubch7-Binding Protein antibody
Anti-Ubcm4-Interacting Protein antibody
Anti-Ubiquitin-Conjugating Enzyme E2-Binding Protein 1 antibody
Anti-ARIH1 antibody
Anti-ARI antibody
Anti-MOP6 antibody
Anti-UBCH7BP antibody
Anti-HUSSY-27 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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