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  • 产品名称：Anti-ARL6IP1 antibody (1-100) (STJ119311)

  • 产品型号：STJ119311
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ARL6IP1 antibody (1-100) (STJ119311)
详情介绍：
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ARL6IP1 (1-100) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ARL6IP1
Gene ID: 23204
Uniprot ID: AR6P1_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ARL6IP1 (NP_055976.1).
Immunogen Sequence: MAEGDNRSTNLLAAETASLE EQLQGWGEVMLMADKVLRWE RAWFPPAIMGVVSLVFLIIY YLDPSVLSGVSCFVMFLCLA DYLVPILAPRIFGSNKWTTE
Tissue Specificity Expressed in all hematopoietic cell lineages, but the highest level of expression is found in early myeloid progenitor cells. Expressed in brain, bone marrow, thymus and lung. Expressed at low level in liver, kidney and spleen. Not detected in heart.
Function Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport. Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself. May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation.
Protein Name Adp-Ribosylation Factor-Like Protein 6-Interacting Protein 1
Arl-6-Interacting Protein 1
Aip-1
Apoptotic Regulator In The Membrane Of The Endoplasmic Reticulum
Cellular Localisation Endomembrane System
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Endoplasmic Reticulum
Predominantly Localized To Intracytoplasmic Membranes
Preferentially Localizes At The Er Tubules And The Edge Of The Er Sheets
Both Of Which Are Characterized By A High Membrane Curvature
Alternative Antibody Names Anti-Adp-Ribosylation Factor-Like Protein 6-Interacting Protein 1 antibody
Anti-Arl-6-Interacting Protein 1 antibody
Anti-Aip-1 antibody
Anti-Apoptotic Regulator In The Membrane Of The Endoplasmic Reticulum antibody
Anti-ARL6IP1 antibody
Anti-ARL6IP antibody
Anti-ARMER antibody
Anti-KIAA0069 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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