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  • 产品名称：Human FUT3 (Fucosyltransferase 3) Sandwich ELISA Kit Ready-To-Use (STJE0015387)

  • 产品型号：STJE0015387
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human FUT3 (Fucosyltransferase 3) Sandwich ELISA Kit Ready-To-Use (STJE0015387)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.062ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This FUT3 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: FUT3
Gene ID: 2525
Uniprot ID: FUT3_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver.
Post Translational Modifications Glycosylated.
Function Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors and participates in the blood groups Lewis determination and expression of Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens. Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sialyl Lewis a expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration. Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin. Prefers type 1 chain over type 2 acceptors. Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred. Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme.
Protein Name 3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase Fut3
4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase
Alpha-3-Fucosyltransferase Fut3
Blood Group Lewis Alpha-4-Fucosyltransferase
Lewis Ft
Fucosyltransferase 3
Fucosyltransferase Iii
Fuct-Iii
Database Links Reactome: R-HSA-9037629
Reactome: R-HSA-975578
Cellular Localisation Golgi Apparatus
Golgi Stack Membrane
Single-Pass Type Ii Membrane Protein
Membrane-Bound Form In Trans Cisternae Of Golgi
Alternative ELISA Names 3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase Fut3 ELISA kit
4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase ELISA kit
Alpha-3-Fucosyltransferase Fut3 ELISA kit
Blood Group Lewis Alpha-4-Fucosyltransferase ELISA kit
Lewis Ft ELISA kit
Fucosyltransferase 3 ELISA kit
Fucosyltransferase Iii ELISA kit
Fuct-Iii ELISA kit
FUT3 ELISA kit
FT3B ELISA kit
LE ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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