产品详情
查看大图

  • 产品名称：Anti-BRCC3 antibody (STJA0008683)

  • 产品型号：STJA0008683
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-BRCC3 antibody (STJA0008683)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Lys-63-specific deubiquitinase BRCC36 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BRCC3
Gene ID: 79184
Uniprot ID: BRCC3_HUMAN
Specificity: This antibody detects endogenous levels of BRCC3 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human BRCC3
Function Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1.deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Acts as a regulator of the NLRP3 inflammasome by mediating deubiquitination of NLRP3, leading to NLRP3 inflammasome assembly. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Deubiquitinates HDAC1 and PWWP2B leading to their stabilization.
Protein Name Lys-63-Specific Deubiquitinase Brcc36
Brca1-A Complex Subunit Brcc36
Brca1/Brca2-Containing Complex Subunit 3
Brca1/Brca2-Containing Complex Subunit 36
Brisc Complex Subunit Brcc36
Database Links Reactome: R-HSA-5689901
Reactome: R-HSA-5693565
Reactome: R-HSA-5693571
Reactome: R-HSA-5693607
Reactome: R-HSA-69473
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Spindle Pole
Localizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs)
Interaction With Abraxas2 Retains Brcc3 In The Cytoplasm
Alternative Antibody Names Anti-Lys-63-Specific Deubiquitinase Brcc36 antibody
Anti-Brca1-A Complex Subunit Brcc36 antibody
Anti-Brca1/Brca2-Containing Complex Subunit 3 antibody
Anti-Brca1/Brca2-Containing Complex Subunit 36 antibody
Anti-Brisc Complex Subunit Brcc36 antibody
Anti-BRCC3 antibody
Anti-BRCC36 antibody
Anti-C6.1A antibody
Anti-CXorf53 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号