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  • 产品名称：Anti-BIRC2 antibody (STJ193113)

  • 产品型号：STJ193113
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BIRC2 antibody (STJ193113)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Baculoviral IAP repeat-containing protein 2 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BIRC2
Gene ID: 329
Uniprot ID: BIRC2_HUMAN
Specificity: BIRC2 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Auto-ubiquitinated and degraded by the proteasome in apoptotic cells. Upon stimulation of death receptors, including TNFRSF10B, recruited to receptors and cleaved by caspases. Proteolytic fragments remain associated with the receptors. This cleavage presumably inactivates the protein.
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.
Protein Name Baculoviral Iap Repeat-Containing Protein 2
Cellular Inhibitor Of Apoptosis 1
C-Iap1
Iap Homolog B
Inhibitor Of Apoptosis Protein 2
Hiap-2
Hiap2
Ring Finger Protein 48
Ring-Type E3 Ubiquitin Transferase Birc2
Tnfr2-Traf-Signaling Complex Protein 2
Database Links Reactome: R-HSA-111465
Reactome: R-HSA-168638
Reactome: R-HSA-168927
Reactome: R-HSA-5213460
Reactome: R-HSA-5357786
Reactome: R-HSA-5357905
Reactome: R-HSA-5357956
Reactome: R-HSA-5668541
Reactome: R-HSA-5675482
Reactome: R-HSA-5676594
Reactome: R-HSA-5689880
Reactome: R-HSA-937041
Cellular Localisation Cytoplasm
Nucleus
Agents That Induce Either The Extrinsic Or Intrinsic Apoptotic Pathways Promote Its Redistribution From The Nuclear Compartment To The Cytoplasmic Compartment
Associated With The Midbody In Telophase Cells
And Found Diffusely In The Nucleus Of Interphase Cells
Alternative Antibody Names Anti-Baculoviral Iap Repeat-Containing Protein 2 antibody
Anti-Cellular Inhibitor Of Apoptosis 1 antibody
Anti-C-Iap1 antibody
Anti-Iap Homolog B antibody
Anti-Inhibitor Of Apoptosis Protein 2 antibody
Anti-Hiap-2 antibody
Anti-Hiap2 antibody
Anti-Ring Finger Protein 48 antibody
Anti-Ring-Type E3 Ubiquitin Transferase Birc2 antibody
Anti-Tnfr2-Traf-Signaling Complex Protein 2 antibody
Anti-BIRC2 antibody
Anti-API1 antibody
Anti-MIHB antibody
Anti-RNF48 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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