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  • 产品名称：Anti-BPIFA1 antibody (20-256) (STJ111354)

  • 产品型号：STJ111354
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BPIFA1 antibody (20-256) (STJ111354)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-BPIFA1 (20-256) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BPIFA1
Gene ID: 51297
Uniprot ID: BPIA1_HUMAN
Immunogen Region: 20-256
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-256 of human BPIFA1 (NP_057667.1).
Immunogen Sequence: QFGGLPVPLDQTLPLNVNPA LPLSPTGLAGSLTNALSNGL LSGGLLGILENLPLLDILKP GGGTSGGLLGGLLGKVTSVI PGLNNIIDIKVTDPQLLELG LVQSPDGHRLYVTIPLGIKL QVNTPLVGASLLRLAVKLDI TAEILAVRDKQERIHLVLGD CTHSPGSLQISLLDGLGPLP IQGLLDSLTGILNKVLPELV QGNVCPLVNEVLRGLDITLV HDIVNMLIHGLQFVIKV
Tissue Specificity Highly expressed in lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium (at protein level). Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues (at protein level). Also expressed in the eye where it is detected in lacrimal gland, eyelid, conjunctiva and cornea (at protein level). Specifically localizes to epithelial cell layers in cornea, eyelid (basal epithelium) and conjunctiva (at protein level). Detected within acinar cells and ducts in the lacrimal and Meibomian glands (at protein level). In lung, shows highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways. Also expressed in lung cancers and some other types of cancer.
Post Translational Modifications May be N-glycosylated.
Function Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils.
Protein Name Bpi Fold-Containing Family A Member 1
Lung-Specific Protein X
Nasopharyngeal Carcinoma-Related Protein
Palate Lung And Nasal Epithelium Clone Protein
Secretory Protein In Upper Respiratory Tracts
Short Plunc1
Splunc1
Tracheal Epithelium-Enriched Protein
Von Ebner Protein Hl
Database Links Reactome: R-HSA-6803157
Cellular Localisation Secreted
Apical Side Of Airway Epithelial Cells
Detected In Airway Surface Liquid
Nasal Mucus And Sputum
Alternative Antibody Names Anti-Bpi Fold-Containing Family A Member 1 antibody
Anti-Lung-Specific Protein X antibody
Anti-Nasopharyngeal Carcinoma-Related Protein antibody
Anti-Palate Lung And Nasal Epithelium Clone Protein antibody
Anti-Secretory Protein In Upper Respiratory Tracts antibody
Anti-Short Plunc1 antibody
Anti-Splunc1 antibody
Anti-Tracheal Epithelium-Enriched Protein antibody
Anti-Von Ebner Protein Hl antibody
Anti-BPIFA1 antibody
Anti-LUNX antibody
Anti-NASG antibody
Anti-PLUNC antibody
Anti-SPLUNC1 antibody
Anti-SPURT antibody
Anti-UNQ787 antibody
Anti-PRO1606 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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