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  • 产品名称：Anti-BTLA antibody (31-241) (STJ115410)

  • 产品型号：STJ115410
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BTLA antibody (31-241) (STJ115410)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-BTLA (31-241) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BTLA
Gene ID: 151888
Uniprot ID: BTLA_HUMAN
Immunogen Region: 31-241
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 31-241 of human BTLA (NP_001078826.1).
Immunogen Sequence: KESCDVQLYIKRQSEHSILA GDPFELECPVKYCANRPHVT WCKLNGTTCVKLEDRQTSWK EEKNISFFILHFEPVLPNDN GSYRCSANFQSNLIESHSTT LYVTGKQNELSDTAGREINL VDAHLKSEQTEASTRQNSQV LLSETGIYDNDPDLCFRMQE GSEVYSNPCLEENKPGIVYA SLNHSVIGPNSRLARNVKEA PTEYASICVRS
Post Translational Modifications Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11. N-glycosylated.
Function Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.
Protein Name B- And T-Lymphocyte Attenuator
B- And T-Lymphocyte-Associated Protein
Cd Antigen Cd272
Database Links Reactome: R-HSA-388841
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-B- And T-Lymphocyte Attenuator antibody
Anti-B- And T-Lymphocyte-Associated Protein antibody
Anti-Cd Antigen Cd272 antibody
Anti-BTLA antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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