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  • 产品名称：Anti-BUB3 antibody (1-100) [S3MR] (STJ11102383)

  • 产品型号：STJ11102383
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BUB3 antibody (1-100) [S3MR] (STJ11102383)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Bub3 (1-100) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: S3MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BUB3
Gene ID: 9184
Uniprot ID: BUB3_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human BUB3 (O43684).
Immunogen Sequence: MTGSNEFKLNQPPEDGISSV KFSPNTSQFLLVSSWDTSVR LYDVPANSMRLKYQHTGAVL DCAFYDPTHAWSGGLDHQLK MHDLNTDQENLVGTHDAPIR
Post Translational Modifications Poly-ADP-ribosylated by PARP1.
Function Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Protein Name Mitotic Checkpoint Protein Bub3
Database Links Reactome: R-HSA-141430
Reactome: R-HSA-141444
Reactome: R-HSA-174184
Reactome: R-HSA-176409
Reactome: R-HSA-179409
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-5663220
Reactome: R-HSA-68877
Reactome: R-HSA-9648025
Cellular Localisation Nucleus
Chromosome
Centromere
Kinetochore
Starts To Localize At Kinetochores In Prometaphase I (Pro-Mi) Stage And Maintains The Localization Until The Metaphase I-Anaphase I (Mi-Ai) Transition
Alternative Antibody Names Anti-Mitotic Checkpoint Protein Bub3 antibody
Anti-BUB3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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