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  • 产品名称：Anti-ASXL1 antibody (1120-1180) {Biotin} (STJ506152)

  • 产品型号：STJ506152-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ASXL1 antibody (1120-1180) {Biotin} (STJ506152)
详情介绍：
Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ASXL1 (1120-1180) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Asxl1
Gene ID: 228790
Uniprot ID: ASXL1_MOUSE
Immunogen Region: 1120-1180
Immunogen: Synthetic peptide taken within amino acid region 1120-1180 on mouse Putative Polycomb group protein ASXL1.
Post Translational Modifications Ubiquitinated by TRIP12, leading to its subsequent degradation following binding N(6)-methyladenosine methylated DNA (m6A).
Function Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator of RARA and RXRA through association with NCOA1. Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing.
Protein Name Polycomb Group Protein Asxl1
Additional Sex Combs-Like Protein 1
Database Links Reactome: R-MMU-5689603
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Polycomb Group Protein Asxl1 antibody
Anti-Additional Sex Combs-Like Protein 1 antibody
Anti-Asxl1 antibody
Anti-Kiaa0978 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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