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  • 产品名称：Anti-CACNA1C antibody (1100-1180) (STJA0010115)

  • 产品型号：STJA0010115
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CACNA1C antibody (1100-1180) (STJA0010115)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Voltage-dependent L-type calcium channel subunit alpha-1C (1100-1180) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CACNA1C
Gene ID: 775
Uniprot ID: CAC1C_HUMAN
Immunogen Region: 1100-1180
Specificity: This antibody detects endogenous levels of Human, Rat, Mouse CACNA1C
Immunogen: Synthesized peptide derived from human CACNA1C AA range: 1100-1180
Post Translational Modifications Phosphorylation by PKA at Ser-1981 activates the channel. Elevated levels of blood glucose lead to increased phosphorylation by PKA.
Function Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). (Microbial infection) Acts as a receptor for Influenzavirus. May play a critical role in allowing virus entry when sialylated and expressed on lung tissues.
Protein Name Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c
Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle
Voltage-Gated Calcium Channel Subunit Alpha Cav1.2
Database Links Reactome: R-HSA-400042
Reactome: R-HSA-419037
Reactome: R-HSA-422356
Reactome: R-HSA-5576892
Reactome: R-HSA-5576893
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Sarcolemma
Perikaryon
Postsynaptic Density Membrane
Cell Projection
Dendrite
T-Tubule
Colocalizes With Ryanodine Receptors In Distinct Clusters At The Junctional Membrane
Where The Sarcolemma And The Sarcoplasmic Reticulum Are In Close Contact
The Interaction Between Rrad And Cacnb2 Promotes The Expression Of Cacna1c At The Cell Membrane
Alternative Antibody Names Anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c antibody
Anti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle antibody
Anti-Voltage-Gated Calcium Channel Subunit Alpha Cav1.2 antibody
Anti-CACNA1C antibody
Anti-CACH2 antibody
Anti-CACN2 antibody
Anti-CACNL1A1 antibody
Anti-CCHL1A1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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