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  • 产品名称：Anti-CACNA1S antibody (STJ11105001)

  • 产品型号：STJ11105001
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CACNA1S antibody (STJ11105001)
详情介绍：
Host: Rabbit
Applications: IF
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1s is suitable for use in Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CACNA1S
Gene ID: 779
Uniprot ID: CAC1S_HUMAN
Immunogen: Recombinant protein of human CACNA1S.
Tissue Specificity Skeletal muscle specific.
Post Translational Modifications The alpha-1S subunit is found in two isoforms in the skeletal muscle: a minor form of 212 kDa containing the complete amino acid sequence, and a major form of 190 kDa derived from the full-length form by post-translational proteolysis close to Phe-1690. Phosphorylated. Phosphorylation by PKA activates the calcium channel. Both the minor and major forms are phosphorylated in vitro by PKA. Phosphorylation at Ser-1575 is involved in beta-adrenergic-mediated regulation of the channel.
Function Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcoplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
Protein Name Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1s
Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 3 - Skeletal Muscle
Voltage-Gated Calcium Channel Subunit Alpha Cav1.1
Database Links Reactome: R-HSA-419037
Cellular Localisation Cell Membrane
Sarcolemma
T-Tubule
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1s antibody
Anti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 3 - Skeletal Muscle antibody
Anti-Voltage-Gated Calcium Channel Subunit Alpha Cav1.1 antibody
Anti-CACNA1S antibody
Anti-CACH1 antibody
Anti-CACN1 antibody
Anti-CACNL1A3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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