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  • 产品名称：Anti-CACNA2D3 antibody (900-1040) (STJ112353)

  • 产品型号：STJ112353
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CACNA2D3 antibody (900-1040) (STJ112353)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CACNA2D3 (900-1040) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CACNA2D3
Gene ID: 55799
Uniprot ID: CA2D3_HUMAN
Immunogen Region: 900-1040
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 900-1040 of human CACNA2D3 (NP_060868.2).
Immunogen Sequence: LYDYQAMCRANKESSDGAHG LLDPYNAFLSAVKWIMTELV LFLVEFNLCSWWHSDMTAKA QKLKQTLEPCDTEYPAFVSE RTIKETTGNIACEDCSKSFV IQQIPSSNLFMVVVDSSCLC ESVAPITMAPIEIRYNESLK C
Tissue Specificity Only detected in brain. Not present in lung, testis, aorta, spleen, jejunum, ventricular muscle and kidney (at protein level). it is brain-specific, while it is widely expressed.
Post Translational Modifications N-glycosylated. May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role.
Function The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G).
Protein Name Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-3
Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-3 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-3 - Voltage-Dependent Calcium Channel Subunit Delta-3
Database Links Reactome: R-HSA-112308
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-3 antibody
Anti-Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-3 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-3 - Voltage-Dependent Calcium Channel Subunit Delta-3 antibody
Anti-CACNA2D3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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