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  • 产品名称：Human HMGA1 (High Mobility Group AT Hook Protein 1) Sandwich ELISA Kit (STJE0009475)

  • 产品型号：STJE0009475
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human HMGA1 (High Mobility Group AT Hook Protein 1) Sandwich ELISA Kit (STJE0009475)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.124ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This HMGA1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: HMGA1
Gene ID: 3159
Uniprot ID: HMGA1_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications Constitutively phosphorylated on two or three sites. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity. HMG-Y is not methylated. Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.
Function HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
Protein Name High Mobility Group Protein Hmg-I/Hmg-Y
Hmg-I(Y
High Mobility Group At-Hook Protein 1
High Mobility Group Protein A1
High Mobility Group Protein R
Database Links Reactome: R-HSA-162592
Reactome: R-HSA-164843
Reactome: R-HSA-175567
Reactome: R-HSA-177539
Reactome: R-HSA-180689
Reactome: R-HSA-180910
Reactome: R-HSA-2559584
Cellular Localisation Nucleus
Chromosome
Alternative ELISA Names High Mobility Group Protein Hmg-I/Hmg-Y ELISA kit
Hmg-I(Y ELISA kit
High Mobility Group At-Hook Protein 1 ELISA kit
High Mobility Group Protein A1 ELISA kit
High Mobility Group Protein R ELISA kit
HMGA1 ELISA kit
HMGIY ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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