产品详情
查看大图

  • 产品名称：Human HSD11b2 (11-Beta-Hydroxysteroid Dehydrogenase Type 2) Sandwich ELISA Kit (STJE0009528)

  • 产品型号：STJE0009528
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Human HSD11b2 (11-Beta-Hydroxysteroid Dehydrogenase Type 2) Sandwich ELISA Kit (STJE0009528)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.057ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This HSD11b2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: HSD11B2
Gene ID: 3291
Uniprot ID: DHI2_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in kidney, placenta, pancreas, prostate, ovary, small intestine and colon, and in lower levels in the spleen and testis. At midgestation, expressed at high levels in placenta and in fetal kidney and, at much lower levels, in fetal lung and testis.
Post Translational Modifications
Function Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as cortisol, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as cortisone, in the presence of NAD(+). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure. Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen. Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone. Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro. 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as ligand for the G-protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration. May protect ovulating oocytes and fertilizing spermatozoa from the adverse effects of cortisol.
Protein Name 11-Beta-Hydroxysteroid Dehydrogenase Type 2
11-Dh2
11-Beta-Hsd2
11-Beta-Hydroxysteroid Dehydrogenase Type Ii
11-Hsd Type Ii
11-Beta-Hsd Type Ii
Corticosteroid 11-Beta-Dehydrogenase Isozyme 2
Nad-Dependent 11-Beta-Hydroxysteroid Dehydrogenase
Short Chain Dehydrogenase/Reductase Family 9c Member 3
Database Links Reactome: R-HSA-194002
Reactome: R-HSA-9757110
Cellular Localisation Microsome
Endoplasmic Reticulum
Alternative ELISA Names 11-Beta-Hydroxysteroid Dehydrogenase Type 2 ELISA kit
11-Dh2 ELISA kit
11-Beta-Hsd2 ELISA kit
11-Beta-Hydroxysteroid Dehydrogenase Type Ii ELISA kit
11-Hsd Type Ii ELISA kit
11-Beta-Hsd Type Ii ELISA kit
Corticosteroid 11-Beta-Dehydrogenase Isozyme 2 ELISA kit
Nad-Dependent 11-Beta-Hydroxysteroid Dehydrogenase ELISA kit
Short Chain Dehydrogenase/Reductase Family 9c Member 3 ELISA kit
HSD11B2 ELISA kit
HSD11K ELISA kit
SDR9C3 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号