产品详情
简单介绍:
Human IL12B (IL12B) Sandwich ELISA Kit (STJE0000008)
详情介绍:
Applications: | ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: | 1.95 pg/mL |
Detection Limit: | 1562-1000 pg/mL |
Short Description: | This IL12B Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
Conjugation: | Biotin |
Storage Instruction: | Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month. |
Assay Time: | 4 hours |
Detection: | Colorimetric |
Gene Symbol: | IL12B |
Gene ID: | 3593 |
Uniprot ID: | IL12B_HUMAN |
Sample Type: | cell culture supernates, serum, EDTA plasma, Heparin plasma |
Tissue Specificity | |
Post Translational Modifications | Known to be C-mannosylated in the recombinant protein.it is not yet known for sure if the wild-type protein is also modified. |
Function | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. |
Protein Name | Interleukin-12 Subunit Beta Il-12b Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit Clmf P40 Il-12 Subunit P40 Nk Cell Stimulatory Factor Chain 2 Nksf2 |
Database Links | Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 Reactome: R-HSA-9020591 Reactome: R-HSA-9020933 |
Cellular Localisation | Secreted |
Alternative ELISA Names | Interleukin-12 Subunit Beta ELISA kit Il-12b ELISA kit Cytotoxic Lymphocyte Maturation Factor 40 Kda Subunit ELISA kit Clmf P40 ELISA kit Il-12 Subunit P40 ELISA kit Nk Cell Stimulatory Factor Chain 2 ELISA kit Nksf2 ELISA kit IL12B ELISA kit NKSF2 ELISA kit |
output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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