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  • 产品名称：Anti-CAV2 antibody (1-100) [S2MR] (STJ11102182)

  • 产品型号：STJ11102182
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CAV2 antibody (1-100) [S2MR] (STJ11102182)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IP
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Caveolin-2 (1-100) is suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation research applications.
Clonality: Monoclonal
Clone ID: S2MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
IP 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CAV2
Gene ID: 858
Uniprot ID: CAV2_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Caveolin-2 (P51636).
Immunogen Sequence: MGLETEKADVQLFMDDDSYS HHSGLEYADPEKFADSDQDR DPHRLNSHLKLGFEDVIAEP VTTHSFDKVWICSHALFEIS KYVMYKFLTVFLAIPLAFIA
Tissue Specificity Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.
Post Translational Modifications Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells. Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin.
Function May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
Protein Name Caveolin-2
Database Links Reactome: R-HSA-9009391
Cellular Localisation Nucleus
Cytoplasm
Golgi Apparatus Membrane
Peripheral Membrane Protein
Cell Membrane
Membrane
Caveola
Potential Hairpin-Like Structure In The Membrane
Membrane Protein Of Caveolae
Tyr-19-Phosphorylated Form Is Enriched At Sites Of Cell-Cell Contact And Is Translocated To The Nucleus In Complex With Mapk1 In Response To Insulin
Tyr-27-Phosphorylated Form Is Located Both In The Cytoplasm And Plasma Membrane
Cav1-Mediated Ser-23-Phosphorylated Form Locates To The Plasma Membrane
Ser-36-Phosphorylated Form Resides In Intracellular Compartments
Alternative Antibody Names Anti-Caveolin-2 antibody
Anti-CAV2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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