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  • 产品名称：Anti-CBX2 antibody (433-532) [S7MR] (STJ11101847)

  • 产品型号：STJ11101847
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CBX2 antibody (433-532) [S7MR] (STJ11101847)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-CBX2 (433-532) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S7MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CBX2
Gene ID: 84733
Uniprot ID: CBX2_HUMAN
Immunogen Region: 433-532
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 433-532 of human CBX2 (Q14781).
Immunogen Sequence: GSATPSGQESRTAPGEARKA ATLPEMSAGEESSSSDSDPD SASPPSTGQNPSVSVQTSQD WKPTRSLIEHVFVTDVTANL ITVTVKESPTSVGFFNLRHY
Function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). Plays a role in the lineage differentiation of the germ layers in embryonic development. Involved in sexual development, acting as activator of NR5A1 expression.
Protein Name Chromobox Protein Homolog 2
Database Links Reactome: R-HSA-2559580
Reactome: R-HSA-3108214
Reactome: R-HSA-3899300
Reactome: R-HSA-4551638
Reactome: R-HSA-4570464
Reactome: R-HSA-4655427
Reactome: R-HSA-8939243
Reactome: R-HSA-8943724
Cellular Localisation Nucleus
Chromosome
Localized In Distinct Foci On Chromatin And In Chromocenters
Localizes To The Inactive X Chromosome
Seems To Be Recruited To H3k27me3
H3k9ac And H3k3me2 Sites On Chromatin
Alternative Antibody Names Anti-Chromobox Protein Homolog 2 antibody
Anti-CBX2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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