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  • 产品名称：Human IL1h (Interleukin 1 Eta) Sandwich ELISA Kit Ready-To-Use (STJE0016236)

  • 产品型号：STJE0016236
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IL1h (Interleukin 1 Eta) Sandwich ELISA Kit Ready-To-Use (STJE0016236)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 6.6pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This IL1h Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: IL36B
Gene ID: 27177
Uniprot ID: IL36B_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue.
Post Translational Modifications N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).
Function Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6.
Protein Name Interleukin-36 Beta
Fil1 Eta
Interleukin-1 Eta
Il-1 Eta
Interleukin-1 Family Member 8
Il-1f8
Interleukin-1 Homolog 2
Il-1h2
Database Links Reactome: R-HSA-9014826
Cellular Localisation Cytoplasm
Secreted
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative ELISA Names Interleukin-36 Beta ELISA kit
Fil1 Eta ELISA kit
Interleukin-1 Eta ELISA kit
Il-1 Eta ELISA kit
Interleukin-1 Family Member 8 ELISA kit
Il-1f8 ELISA kit
Interleukin-1 Homolog 2 ELISA kit
Il-1h2 ELISA kit
IL36B ELISA kit
IL1F8 ELISA kit
IL1H2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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