产品详情
查看大图

  • 产品名称：Human IL1z (Interleukin 1 Zeta) Sandwich ELISA Kit (STJE0007145)

  • 产品型号：STJE0007145
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Human IL1z (Interleukin 1 Zeta) Sandwich ELISA Kit (STJE0007145)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 24pg/mL
Detection Limit: 78.1-5000pg/mL
Short Description: This IL1z Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: IL37
Gene ID: 27178
Uniprot ID: IL37_HUMAN
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity In general, low constitutive expression, if any, in healthy tissues.high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.
Post Translational Modifications Proteolytically converted to the mature form by CASP1.
Function Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. Signaling can occur via two mechanisms, intracellularly through nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor composed of IL18R1 and IL18RAP. Suppresses, or reduces, pro-inflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
Protein Name Interleukin-37
Il-37
Fil1 Zeta
Il-1x
Interleukin-1 Family Member 7
Il-1f7
Interleukin-1 Homolog 4
Il-1h
Il-1h4
Interleukin-1 Zeta
Il-1 Zeta
Interleukin-1-Related Protein
Il-1rp1
Database Links Reactome: R-HSA-9008059
Reactome: R-HSA-9012546
Cellular Localisation Cytoplasm
Cytosol
Nucleus
Secreted
Stimulation With Il1b Leads To Colocalization With Smad3 Mostly In Perinuclear Regions
Only The Casp1-Cleaved Mature Form Translocates Into The Nucleus Upon Lps Stimulation
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative ELISA Names Interleukin-37 ELISA kit
Il-37 ELISA kit
Fil1 Zeta ELISA kit
Il-1x ELISA kit
Interleukin-1 Family Member 7 ELISA kit
Il-1f7 ELISA kit
Interleukin-1 Homolog 4 ELISA kit
Il-1h ELISA kit
Il-1h4 ELISA kit
Interleukin-1 Zeta ELISA kit
Il-1 Zeta ELISA kit
Interleukin-1-Related Protein ELISA kit
Il-1rp1 ELISA kit
IL37 ELISA kit
FIL1Z ELISA kit
IL1F7 ELISA kit
IL1H4 ELISA kit
IL1RP1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号