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  • 产品名称：Human IL2 (IL2) Sandwich ELISA Kit (STJE0000002)

  • 产品型号：STJE0000002-96
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IL2 (IL2) Sandwich ELISA Kit (STJE0000002)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.39 pg/mL
Detection Limit: 078-50 pg/ml
Short Description: This IL2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Conjugation: Biotin
Storage Instruction: Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time: 4 hours
Detection: Colorimetric
Gene Symbol: IL2
Gene ID: 3558
Uniprot ID: IL2_HUMAN
Sample Type: serum, plasma and cell culture supernates
Tissue Specificity
Post Translational Modifications
Function Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.
Protein Name Interleukin-2
Il-2
T-Cell Growth Factor
Tcgf
Aldesleukin
Database Links Reactome: R-HSA-5673001
Reactome: R-HSA-8877330
Reactome: R-HSA-9020558
Reactome: R-HSA-912526
Cellular Localisation Secreted
Alternative ELISA Names Interleukin-2 ELISA kit
Il-2 ELISA kit
T-Cell Growth Factor ELISA kit
Tcgf ELISA kit
Aldesleukin ELISA kit
IL2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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