产品详情
简单介绍：
Anti-AS160/TBC1D4 antibody (Internal) (STJ71082)
详情介绍：
| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Goat polyclonal antibody anti-AS160/TBC1D4 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | WB-0.1-0.3µg/ml IHC-Recommended concentration, 3-5µg/ml ELISA-antibody detection limit dilution 1:128000. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | TBC1D4 |
| Gene ID: | 9882 |
| Uniprot ID: | TBCD4_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_055647.2 |
| Immunogen Sequence: | DDPEKIEERKKSK |
| Post Translational Modifications | Phosphorylated by AKT1.insulin-induced. Also phosphorylated by AMPK in response to insulin. Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation. Has no effect on SLC2A4/GLUT4 internalization. Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients. |
| Function | May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. |
| Protein Name | Tbc1 Domain Family Member 4 Akt Substrate Of 160 Kda As160 |
| Database Links | Reactome: R-HSA-1445148 |
| Cellular Localisation | Cytoplasm Isoform 2 Shows A Cytoplasmic Perinuclear Localization In A Myoblastic Cell Line In Resting And Insulin-Stimulated Cells |
| Alternative Antibody Names | Anti-Tbc1 Domain Family Member 4 antibody Anti-Akt Substrate Of 160 Kda antibody Anti-As160 antibody Anti-TBC1D4 antibody Anti-AS160 antibody Anti-KIAA0603 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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