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  • 产品名称：Human HAT1 (Histone Acetyltransferase 1) Sandwich ELISA Kit (STJE0009393)

  • 产品型号：STJE0009393
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human HAT1 (Histone Acetyltransferase 1) Sandwich ELISA Kit (STJE0009393)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.103ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This HAT1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: HAT1
Gene ID: 8520
Uniprot ID: HAT1_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylated by AMPK at Ser-190.phosphorylation increases HAT1 activity.
Function Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression. Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks. In addition, acetylates other substrates such as chromatin-related proteins. Acetylates also RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation. (Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell.
Protein Name Histone Acetyltransferase Type B Catalytic Subunit
Histone Acetyltransferase 1
Database Links Reactome: R-HSA-3214847
Cellular Localisation Isoform A: Nucleus Matrix
Mitochondrion
Isoform B: Cytoplasm
Nucleus
Nucleus Matrix
Nucleoplasm
Localization Is Predominantly Nuclear In Normal Cells
Treatment With Hydrogen Peroxide Or Ionizing Radiation Enhances Nuclear Localization Through Redistribution Of Existing Protein
Alternative ELISA Names Histone Acetyltransferase Type B Catalytic Subunit ELISA kit
Histone Acetyltransferase 1 ELISA kit
HAT1 ELISA kit
KAT1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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