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  • 产品名称：Human IL1e (Interleukin 1 Epsilon) Sandwich ELISA Kit (STJE0009849)

  • 产品型号：STJE0009849
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IL1e (Interleukin 1 Epsilon) Sandwich ELISA Kit (STJE0009849)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 5.1pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This IL1e Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: IL36A
Gene ID: 27179
Uniprot ID: IL36A_HUMAN
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin.
Post Translational Modifications N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold).
Function Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response.similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes up-regulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by up-regulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in pro-inflammatory effects in the lung.
Protein Name Interleukin-36 Alpha
Fil1 Epsilon
Interleukin-1 Epsilon
Il-1 Epsilon
Interleukin-1 Family Member 6
Il-1f6
Database Links Reactome: R-HSA-9014826
Cellular Localisation Cytoplasm
Secreted
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative ELISA Names Interleukin-36 Alpha ELISA kit
Fil1 Epsilon ELISA kit
Interleukin-1 Epsilon ELISA kit
Il-1 Epsilon ELISA kit
Interleukin-1 Family Member 6 ELISA kit
Il-1f6 ELISA kit
IL36A ELISA kit
FIL1E ELISA kit
IL1E ELISA kit
IL1F6 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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