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  • 产品名称：Anti-CCAR2 antibody (431-480 aa) (STJ92659)

  • 产品型号：STJ92659
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CCAR2 antibody (431-480 aa) (STJ92659)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cell cycle and apoptosis regulator protein 2 (431-480 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCAR2
Gene ID: 57805
Uniprot ID: CCAR2_HUMAN
Immunogen Region: 431-480 aa
Specificity: DBC-1 Polyclonal Antibody detects endogenous levels of DBC-1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human KIthe amino acid1967 at the amino acid range 431-480
Post Translational Modifications ATM/ATR-mediated phosphorylation at Thr-454 upon DNA damage promotes binding to SIRT1. Phosphorylation at Thr-454 promotes its sumoylation by switching the binding partner of CCAR2 from SENP1 to PIAS3. Acetylation at Lys-112 and Lys-215 by KAT8 prevents inhibitory binding to SIRT1 and increases its deacetylase activity. Genotoxic stress induces its sumoylation and sumoylation promotes the SIRT1-CCAR2 interaction which in turn inhibits SIRT1-mediated deacetylation of p53/TP53. Sumoylation leads to transcriptional activation of p53/TP53 by sequestering SIRT1 from p53/TP53. Desumoylated by SENP1.
Function Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. Mediates ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation. Represses the ligand-dependent transcriptional activation function of ESR2. Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1. Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization. Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway. Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3. Plays an important role in tumor suppression through p53/TP53 regulation.stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2. Represses the transcriptional activator activity of BRCA1. Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro.
Protein Name Cell Cycle And Apoptosis Regulator Protein 2
Cell Division Cycle And Apoptosis Regulator Protein 2
Dbird Complex Subunit Kiaa1967
Deleted In Breast Cancer Gene 1 Protein
Dbc-1
Dbc.1
Net35
P30 Dbc
Database Links Reactome: R-HSA-3371453
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Spindle
Recruited To Chromatin
Post-Uv Irradiation
Sequestered To The Cytoplasm In The Presence Of Mcc
Translocated To The Cytoplasm During Uv-Induced Apoptosis
Alternative Antibody Names Anti-Cell Cycle And Apoptosis Regulator Protein 2 antibody
Anti-Cell Division Cycle And Apoptosis Regulator Protein 2 antibody
Anti-Dbird Complex Subunit Kiaa1967 antibody
Anti-Deleted In Breast Cancer Gene 1 Protein antibody
Anti-Dbc-1 antibody
Anti-Dbc.1 antibody
Anti-Net35 antibody
Anti-P30 Dbc antibody
Anti-CCAR2 antibody
Anti-DBC1 antibody
Anti-KIAA1967 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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