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  • 产品名称：Anti-AUP1 antibody (STJA0004897)

  • 产品型号：STJA0004897
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AUP1 antibody (STJA0004897)
详情介绍：
Host: Rabbit
Applications: WB/IHC/ELISA
Reactivity: Human/Mouse/Rat
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Lipid Droplet-Regulating Vldl Assembly Factor Aup1 is suitable for use in Western Blot, Immunohistochemistry and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification: Affinity purification
Concentration: 0.5 mg/mL
Dilution Range: WB 1:500-1:2000, IHC 1:50-1:200
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Gene Symbol: AUP1
Gene ID: 550
Uniprot ID: AUP1_HUMAN
Immunogen: Recombinant protein of human AUP1
Tissue Specificity Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.
Post Translational Modifications Monoubiquitinated and diubiquitinated. (Microbial infection) Not ubiquitinated following Dengue virus infection.
Function Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering. Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation. Also required for the degradation of INSIG1, SREBF1 and SREBF2. Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB. (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles.
Protein Name Lipid Droplet-Regulating Vldl Assembly Factor Aup1
Ancient Ubiquitous Protein 1
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Lipid Droplet
Cytoplasmic Vesicle
Autophagosome
(Microbial Infection) Upon Dengue Virus Infection
Relocates From Lipid Droplets To Autophagosomes
Alternative Antibody Names Anti-Lipid Droplet-Regulating Vldl Assembly Factor Aup1 antibody
Anti-Ancient Ubiquitous Protein 1 antibody
Anti-AUP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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