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  • 产品名称：Anti-AURKC antibody (N-Term) (STJ72141)

  • 产品型号：STJ72141-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AURKC antibody (N-Term) (STJ72141)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-AURKC (N-Term) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-1-3µg/ml
ELISA-antibody detection limit dilution 1:64000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: AURKC
Gene ID: 6795
Uniprot ID: AURKC_HUMAN
Immunogen Region: N-Term
Accession Number: NP_001015878.1
Specificity: This antibody is expected to recognize isoform 1 (NP_001015878.1) only.
Immunogen Sequence: PRAVVQLGKAQP
Function Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Protein Name Aurora Kinase C
Aurora 3
Aurora/Ipl1-Related Kinase 3
Ark-3
Aurora-Related Kinase 3
Aurora/Ipl1/Eg2 Protein 2
Serine/Threonine-Protein Kinase 13
Serine/Threonine-Protein Kinase Aurora-C
Cellular Localisation Nucleus
Chromosome
Centromere
Cytoplasm
Cytoskeleton
Spindle
Distributes In The Condensed Chromosomes During Prophase To Metaphase
After Entering Anaphase
There Is A Dissociation From Separated Chromosomes And A Redistribution To Midzone Microtubules
And Finally Remains In The Midbody During Cytokinesis
Alternative Antibody Names Anti-Aurora Kinase C antibody
Anti-Aurora 3 antibody
Anti-Aurora/Ipl1-Related Kinase 3 antibody
Anti-Ark-3 antibody
Anti-Aurora-Related Kinase 3 antibody
Anti-Aurora/Ipl1/Eg2 Protein 2 antibody
Anti-Serine/Threonine-Protein Kinase 13 antibody
Anti-Serine/Threonine-Protein Kinase Aurora-C antibody
Anti-AURKC antibody
Anti-AIE2 antibody
Anti-AIK3 antibody
Anti-AIRK3 antibody
Anti-ARK3 antibody
Anti-STK13 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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