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  • 产品名称：Human IL33 (IL33) Sandwich ELISA Kit (STJE0000093)

  • 产品型号：STJE0000093-96
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IL33 (IL33) Sandwich ELISA Kit (STJE0000093)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 7.8 pg/mL
Detection Limit: 234-1500 pg/ml
Short Description: This IL33 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Conjugation: Biotin
Storage Instruction: Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time: 4 hours
Detection: Colorimetric
Gene Symbol: IL33
Gene ID: 90865
Uniprot ID: IL33_HUMAN
Sample Type: serum, plasma and cell culture supernates
Tissue Specificity Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.
Post Translational Modifications The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CELA1, CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full length protein. May also be proteolytically processed by calpains. Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation. In vitro proteolytic cleavage by CASP1 was reported but could not be confirmed in vivo suggesting that IL33 is probably not a direct substrate for that caspase.
Function Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as an enhancer of polarization of alternatively activated macrophages. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or pro-inflammatory activation.
Protein Name Interleukin-33
Il-33
Interleukin-1 Family Member 11
Il-1f11
Nuclear Factor From High Endothelial Venules
Nf-Hev Cleaved Into - Interleukin-33
95-270 - Interleukin-33
99-270 - Interleukin-33
109-270
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-5689880
Reactome: R-HSA-6811558
Reactome: R-HSA-9014843
Cellular Localisation Nucleus
Chromosome
Cytoplasm
Cytoplasmic Vesicle
Secretory Vesicle
Secreted
Secreted And Released In The Extracellular Milieu By Passing Through The Gasdermin-D (Gsdmd) Pore Following Cleavage By Cela1
Associates With Heterochromatin And Mitotic Chromosomes
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
Alternative ELISA Names Interleukin-33 ELISA kit
Il-33 ELISA kit
Interleukin-1 Family Member 11 ELISA kit
Il-1f11 ELISA kit
Nuclear Factor From High Endothelial Venules ELISA kit
Nf-Hev Cleaved Into - Interleukin-33 ELISA kit
95-270 - Interleukin-33 ELISA kit
99-270 - Interleukin-33 ELISA kit
109-270 ELISA kit
IL33 ELISA kit
C9orf26 ELISA kit
IL1F11 ELISA kit
NFHEV ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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