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  • 产品名称：Human IL4 (IL4) Sandwich ELISA Kit (STJE0000003)

  • 产品型号：STJE0000003-96
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IL4 (IL4) Sandwich ELISA Kit (STJE0000003)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 15.2 pg/mL
Detection Limit: 312-2000 pg/ml
Short Description: This IL4 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Conjugation: Biotin
Storage Instruction: Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time: 4 hours
Detection: Colorimetric
Gene Symbol: IL4
Gene ID: 3565
Uniprot ID: IL4_HUMAN
Sample Type: serum, plasma and cell culture supernates
Tissue Specificity
Post Translational Modifications
Function Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1. Regulates also the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning. Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is expressed also on nonhematopoietic cells. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6.
Protein Name Interleukin-4
Il-4
B-Cell Stimulatory Factor 1
Bsf-1
Binetrakin
Lymphocyte Stimulatory Factor 1
Pitrakinra
Database Links Reactome: R-HSA-6785807
Reactome: R-HSA-9012546
Cellular Localisation Secreted
Alternative ELISA Names Interleukin-4 ELISA kit
Il-4 ELISA kit
B-Cell Stimulatory Factor 1 ELISA kit
Bsf-1 ELISA kit
Binetrakin ELISA kit
Lymphocyte Stimulatory Factor 1 ELISA kit
Pitrakinra ELISA kit
IL4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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