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  • 产品名称：Anti-CCL5 antibody (35-84 aa) (STJ95367)

  • 产品型号：STJ95367
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CCL5 antibody (35-84 aa) (STJ95367)
详情介绍：
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-C-C motif chemokine 5 (35-84 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCL5
Gene ID: 6352
Uniprot ID: CCL5_HUMAN
Immunogen Region: 35-84 aa
Specificity: RANTES Polyclonal Antibody detects endogenous levels of RANTES protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human RANTES at the amino acid range 35-84
Post Translational Modifications N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells. N-terminal processed form RANTES(4-68) is produced by proteolytic cleavage by cathepsin CTSG. The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.
Function Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.
Protein Name C-C Motif Chemokine 5
Eocp
Eosinophil Chemotactic Cytokine
Sis-Delta
Small-Inducible Cytokine A5
T Cell-Specific Protein P228
Tcp228
T-Cell-Specific Protein Rantes Cleaved Into - Rantes(3-68 - Rantes(4-68
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-6783783
Cellular Localisation Secreted
Alternative Antibody Names Anti-C-C Motif Chemokine 5 antibody
Anti-Eocp antibody
Anti-Eosinophil Chemotactic Cytokine antibody
Anti-Sis-Delta antibody
Anti-Small-Inducible Cytokine A5 antibody
Anti-T Cell-Specific Protein P228 antibody
Anti-Tcp228 antibody
Anti-T-Cell-Specific Protein Rantes Cleaved Into - Rantes(3-68 - Rantes(4-68 antibody
Anti-CCL5 antibody
Anti-D17S136E antibody
Anti-SCYA5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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