产品详情
简单介绍:
Anti-CCNA2 antibody (1-200) (STJ22941)
详情介绍:
Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Cyclin A2 (1-200) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CCNA2 |
Gene ID: | 890 |
Uniprot ID: | CCNA2_HUMAN |
Immunogen Region: | 1-200 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human Cyclin A2 (NP_001228.1). |
Immunogen Sequence: | MLGNSAPGPATREAGSALLA LQQTALQEDQENINPEKAAP VQQPRTRAALAVLKSGNPRG LAQQQRPKTRRVAPLKDLPV NDEHVTVPPWKANSKQPAFT IHVDEAEKEAQKKPAESQKI EREDALAFNSAISLPGPRKP LVPLDYPMDGSFESPHTMDM SIVLEDEKPVSVNEVPDYHE DIHTYLREMEVKCKPKVGYM |
Post Translational Modifications | Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. |
Function | Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. |
Protein Name | Cyclin-A2 Cyclin-A Cyclin A |
Database Links | Reactome: R-HSA-1362300 Reactome: R-HSA-1538133 Reactome: R-HSA-170145 Reactome: R-HSA-171319 Reactome: R-HSA-174184 Reactome: R-HSA-176408 Reactome: R-HSA-187577 Reactome: R-HSA-2559582 Reactome: R-HSA-2559586 Reactome: R-HSA-5689880 Reactome: R-HSA-5693607 Reactome: R-HSA-6804116 Reactome: R-HSA-6804756 Reactome: R-HSA-6804757 Reactome: R-HSA-68911 Reactome: R-HSA-68949 Reactome: R-HSA-69017 Reactome: R-HSA-69273 Reactome: R-HSA-69563 Reactome: R-HSA-69656 |
Cellular Localisation | Nucleus Cytoplasm Exclusively Nuclear During Interphase Detected In The Nucleus And The Cytoplasm At Prophase Cytoplasmic When Associated With Scaper |
Alternative Antibody Names | Anti-Cyclin-A2 antibody Anti-Cyclin-A antibody Anti-Cyclin A antibody Anti-CCNA2 antibody Anti-CCN1 antibody Anti-CCNA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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