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  • 产品名称：Anti-CCND3 antibody [6H4] (STJ97979)

  • 产品型号：STJ97979
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CCND3 antibody [6H4] (STJ97979)
详情介绍：
Host: Mouse
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-G1/S-specific cyclin-D3 is suitable for use in Western Blot and ELISA research applications.
Clonality: Monoclonal
Clone ID: 6H4
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCND3
Gene ID: 896
Uniprot ID: CCND3_HUMAN
Specificity: Cyclin D3 Monoclonal Antibody detects endogenous levels of Cyclin D3 protein.
Immunogen: Purified recombinant fragment of human Cyclin D3 expressed in E. Coli.
Function Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4.
Protein Name G1/S-Specific Cyclin-D3
Database Links Reactome: R-HSA-381340
Reactome: R-HSA-5687128
Reactome: R-HSA-69231
Reactome: R-HSA-8934593
Reactome: R-HSA-9661069
Reactome: R-HSA-9754119
Cellular Localisation Nucleus
Cytoplasm
Alternative Antibody Names Anti-G1/S-Specific Cyclin-D3 antibody
Anti-CCND3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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