产品详情
查看大图

  • 产品名称：Human KDM4A (Lysine Specific Demethylase 4A) Sandwich ELISA Kit (STJE0010142)

  • 产品型号：STJE0010142
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Human KDM4A (Lysine Specific Demethylase 4A) Sandwich ELISA Kit (STJE0010142)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.128ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This KDM4A Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: KDM4A
Gene ID: 9682
Uniprot ID: KDM4A_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Ubiquitous.
Post Translational Modifications Ubiquitinated by RNF8 and RNF168 following DNA damage, leading to its degradation. Degradation promotes accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited.
Function Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.
Protein Name Lysine-Specific Demethylase 4a
Jmjc Domain-Containing Histone Demethylation Protein 3a
Jumonji Domain-Containing Protein 2a
Histone H3-Trimethyl-L-Lysine(36 Demethylase 4a
Histone H3-Trimethyl-L-Lysine(9 Demethylase 4a
Database Links Reactome: R-HSA-3214842
Reactome: R-HSA-5693565
Reactome: R-HSA-9029569
Cellular Localisation Nucleus
Alternative ELISA Names Lysine-Specific Demethylase 4a ELISA kit
Jmjc Domain-Containing Histone Demethylation Protein 3a ELISA kit
Jumonji Domain-Containing Protein 2a ELISA kit
Histone H3-Trimethyl-L-Lysine(36 Demethylase 4a ELISA kit
Histone H3-Trimethyl-L-Lysine(9 Demethylase 4a ELISA kit
KDM4A ELISA kit
JHDM3A ELISA kit
JMJD2 ELISA kit
JMJD2A ELISA kit
KIAA0677 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号