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  • 产品名称：Anti-CCR4 antibody (1-100) (STJ119454)

  • 产品型号：STJ119454
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CCR4 antibody (1-100) (STJ119454)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CCR4 (1-100) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCR4
Gene ID: 1233
Uniprot ID: CCR4_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR4 (NP_005499.1).
Immunogen Sequence: MNPTDIADTTLDESIYSNYY LYESIPKPCTKEGIKAFGEL FLPPLYSLVFVFGLLGNSVV VLVLFKYKRLRSMTDVYLLN LAISDLLFVFSLPFWGYYAA
Tissue Specificity Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets.at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.
Post Translational Modifications In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
Function High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Protein Name C-C Chemokine Receptor Type 4
C-C Ckr-4
Cc-Ckr-4
Ccr-4
Ccr4
K5-5
Cd Antigen Cd194
Database Links Reactome: R-HSA-380108
Reactome: R-HSA-418594
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-C-C Chemokine Receptor Type 4 antibody
Anti-C-C Ckr-4 antibody
Anti-Cc-Ckr-4 antibody
Anti-Ccr-4 antibody
Anti-Ccr4 antibody
Anti-K5-5 antibody
Anti-Cd Antigen Cd194 antibody
Anti-CCR4 antibody
Anti-CMKBR4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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