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  • 产品名称：Anti-BBS4 antibody (33-46) (STJ72457)

  • 产品型号：STJ72457-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BBS4 antibody (33-46) (STJ72457)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Dog/Pig
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-BBS4 (33-46) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-1-3µg/ml
ELISA-antibody detection limit dilution 1:1000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: BBS4
Gene ID: 585
Uniprot ID: BBS4_HUMAN
Immunogen Region: 33-46
Accession Number: NP_149017.2
Immunogen Sequence: EKQNWLIHLHYIRK
Function The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome.
Protein Name Bardet-Biedl Syndrome 4 Protein
Database Links Reactome: R-HSA-5620922
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Cell Projection
Cilium Membrane
Centriolar Satellite
Cilium
Flagellum
Localizes To The Pericentriolar Material
Centrosomal Localization Requires Dynein
Localizes To The Connecting Cilium Of Photoreceptor Cells
Alternative Antibody Names Anti-Bardet-Biedl Syndrome 4 Protein antibody
Anti-BBS4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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