产品详情
简单介绍：
Anti-CD11b antibody [EBS-CD-010] (STJ16101084)
详情介绍：
| Host: | Mouse |
| Applications: | FC/IF/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-CD11b is suitable for use in Flow Cytometry, Immunofluorescence and Immunohistochemistry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | EBS-CD-010 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1k |
| Formulation: | PBS with 0.02% Sodium Azide. |
| Purification: | Affinity purified from tissue culture. |
| Concentration: | Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Dilution Range: | Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Immunofluorescence (0, 5-1, 0 µg/ml). Immunohistology (1-2 µg/ml for 30 min at RT; an appropriate antigen retrieval method for staining of formalin-fixed tissues has not been established to date |
| Storage Instruction: | Store for up to 1 year at 2-8°C upon receipt. |
| Gene Symbol: | ITGAM |
| Gene ID: | 3684 |
| Uniprot ID: | ITAM_HUMAN |
| Immunogen: | A BALB/c mouse was immunized with human neutrophils. Fusion partner: P3-X63-Ag8.653. |
| Tissue Specificity | Predominantly expressed in monocytes and granulocytes. Expressed in neutrophils (at protein level). |
| Function | Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development. |
| Protein Name | Integrin Alpha-M Cd11 Antigen-Like Family Member B Cr-3 Alpha Chain Cell Surface Glycoprotein Mac-1 Subunit Alpha Leukocyte Adhesion Receptor Mo1 Neutrophil Adherence Receptor Cd Antigen Cd11b |
| Database Links | Reactome: R-HSA-166016 Reactome: R-HSA-202733 Reactome: R-HSA-216083 Reactome: R-HSA-6785807 Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Membrane Raft |
| Alternative Antibody Names | Anti-Integrin Alpha-M antibody Anti-Cd11 Antigen-Like Family Member B antibody Anti-Cr-3 Alpha Chain antibody Anti-Cell Surface Glycoprotein Mac-1 Subunit Alpha antibody Anti-Leukocyte Adhesion Receptor Mo1 antibody Anti-Neutrophil Adherence Receptor antibody Anti-Cd Antigen Cd11b antibody Anti-ITGAM antibody Anti-CD11B antibody Anti-CR3A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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