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  • 产品名称：Anti-BCAR1 antibody (C-Term) [M144] (STJA0005507)

  • 产品型号：STJA0005507-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BCAR1 antibody (C-Term) [M144] (STJA0005507)
详情介绍：
Host: Mouse
Applications: WB/ICC/IHC/IP
Reactivity: Chicken/Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-p130 Cas (C-Term) is suitable for use in Western Blot, Immunocytochemistry, Immunohistochemistry and Immunoprecipitation research applications.
Clonality: Monoclonal
Clone ID: M144
Conjugation: Unconjugated
Isotype: IgG1
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB 1:1000
IHC 1:250
ICC 1:200
IP 1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Bcar1
Gene ID: 25414
Uniprot ID: BCAR1_RAT
Immunogen Region: C-Term
Specificity: The antibody detects a 130 kDa* protein corresponding to the molecular mass of p130 Cas on SDS-PAGE immunoblots of human A431, endothelial, and Hct116 cells.
Immunogen: Clone M144 was generated from a recombinant protein containing amino acid residues in the C-terminal region of rat p130 Cas. This rat sequence is highly conserved in human, mouse, and chicken p130 Cas.
Post Translational Modifications PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif.phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix. Phosphorylated by SRC kinase in a EDN1- and PTK2B-mediated manner.phosphorylation strengthens its interaction with BCAR3 as part of the PTK2B/BCAR1/BCAR3/RAP1 signaling pathway. Dephosphorylated by PTPN14 at Tyr-226.
Function Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration and cell branching. Involved in the BCAR3-mediated inhibition of TGFB signaling.
Protein Name Breast Cancer Anti-Estrogen Resistance Protein 1
Crk-Associated Substrate
P130cas
Database Links Reactome: R-RNO-186763
Reactome: -RNO-372708
Reactome: -RNO-4420097
Reactome: -RNO-8849471
Cellular Localisation Cell Junction
Focal Adhesion
Cytoplasm
Cell Projection
Axon
Unphosphorylated Form Localizes In The Cytoplasm
Localizes To Focal Adhesion Sites Following Integrin Engagement
Alternative Antibody Names Anti-Breast Cancer Anti-Estrogen Resistance Protein 1 antibody
Anti-Crk-Associated Substrate antibody
Anti-P130cas antibody
Anti-Bcar1 antibody
Anti-Cas antibody
Anti-Crkas antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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