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  • 产品名称：Anti-BCAS3 antibody (674-913) (STJ29413)

  • 产品型号：STJ29413
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BCAS3 antibody (674-913) (STJ29413)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF/IP
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-BCAS3 (674-913) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and Immunoprecipitation research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
IP 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BCAS3
Gene ID: 54828
Uniprot ID: BCAS3_HUMAN
Immunogen Region: 674-913
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 674-913 of human BCAS3 (NP_060149.3).
Immunogen Sequence: LAGLVPPGSPGPITRHGSYD SLASDHSGQEDEEWLSQVEI VTHTGPHRRLWMGPQFQFKT IHPSGQTTVISSSSSVLQSH GPSDTPQPLLDFDTDDLDLN SLRIQPVRSDPVSMPGSSRP VSDRRGVSTVIDAASGTFDR SVTLLEVCGSWPEGFGLRHM SSMEHTEEGLRERLADAMAE SPSRDVVGSGTELQREGSIE TLSNSSGSTSGSIPRNFDGY RSPLPTNESQPLSLFPTGF
Tissue Specificity Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Expressed in undifferentiated ES cells. Expressed in blood islands and nascent blood vessels derived from differentiated ES cells into embryoid bodies (BD). Expressed in endothelial cells. Not detected in brain. Expressed in brain tumors (at protein level). Expressed in brain. Highly expressed in breast cancers and in glioma cell lines.
Function Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy. Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures.
Protein Name Bcas3 Microtubule Associated Cell Migration Factor
Breast Carcinoma-Amplified Sequence 3
Gaob1
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Preautophagosomal Structure
Localizes In The Cytoplasm In Stationary Cells
Translocates From The Cytoplasm To The Leading Edge In Motile Cells
Colocalizes With Microtubules And Intermediate Filaments In Both Stationary And Motile Cells
Associates With Chromatin
Recruited To Estrogen Receptor-Induced Promoters In A Pelp1-Dependent Manner
The Bcas3:Phaf1 Complex Is Recruited To The Preautophagosomal Structures Adjacent To The Damaged Mitochondria Upon Mitophagy In A Prkn-Pink1 Dependent Manner
Alternative Antibody Names Anti-Bcas3 Microtubule Associated Cell Migration Factor antibody
Anti-Breast Carcinoma-Amplified Sequence 3 antibody
Anti-Gaob1 antibody
Anti-BCAS3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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