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  • 产品名称：Anti-CD14 antibody (1-100 aa) [ABT-CD14] (STJ196787)

  • 产品型号：STJ196787
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD14 antibody (1-100 aa) [ABT-CD14] (STJ196787)
详情介绍：
Host: Mouse
Applications: IHC/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Monocyte differentiation antigen CD14 (1-100 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: ABT-CD14
Conjugation: Unconjugated
Isotype: IgG2bk
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Dilution Range: IHC-P 1:100-500
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CD14
Gene ID: 929
Uniprot ID: CD14_HUMAN
Immunogen Region: 1-100 aa
Specificity: This antibody detects endogenous levels of human CD14. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section
Immunogen: Synthesized peptide derived from the human CD14 at the amino acid range 1-100
Post Translational Modifications N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
Function Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-).
Protein Name Monocyte Differentiation Antigen Cd14
Myeloid Cell-Specific Leucine-Rich Glycoprotein
Cd Antigen Cd14 Cleaved Into - Monocyte Differentiation Antigen Cd14 - Urinary Form - Monocyte Differentiation Antigen Cd14 - Membrane-Bound Form
Database Links Reactome: R-HSA-1236974
Reactome: R-HSA-140534
Reactome: R-HSA-166016
Reactome: R-HSA-166020
Reactome: R-HSA-166058
Reactome: R-HSA-166166
Reactome: R-HSA-168179
Reactome: R-HSA-168188
Reactome: R-HSA-2562578
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Reactome: R-HSA-5686938
Reactome: R-HSA-6798695
Reactome: R-HSA-936964
Reactome: R-HSA-937041
Reactome: R-HSA-937072
Reactome: R-HSA-975163
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Membrane Raft
Golgi Apparatus
Secreted Forms May Arise By Cleavage Of The Gpi Anchor
Alternative Antibody Names Anti-Monocyte Differentiation Antigen Cd14 antibody
Anti-Myeloid Cell-Specific Leucine-Rich Glycoprotein antibody
Anti-Cd Antigen Cd14 Cleaved Into - Monocyte Differentiation Antigen Cd14 - Urinary Form - Monocyte Differentiation Antigen Cd14 - Membrane-Bound Form antibody
Anti-CD14 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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