产品详情
查看大图

  • 产品名称：Anti-CD154/CD40LG antibody [5C8] {Biotin} (STJA0001808)

  • 产品型号：STJA0001808
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-CD154/CD40LG antibody [5C8] {Biotin} (STJA0001808)
详情介绍：
Host: Mouse
Applications: FC
Reactivity: Human/Monkey
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD40 ligand is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: 5C8
Conjugation: Biotin
Isotype: IgG2ak
Formulation: PBS with 0.05% Proclin300, 1% BSA
Concentration: 0.5 mg/mL
Storage Instruction: Store at 2-8°C. Do not freeze this product.
Gene Symbol: CD40LG
Gene ID: 959
Uniprot ID: CD40L_HUMAN
Tissue Specificity Specifically expressed on activated CD4+ T-lymphocytes.
Post Translational Modifications The soluble form derives from the membrane form by proteolytic processing. N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40. Not O-glycosylated.
Function Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B. Induces the activation of kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. CD40 ligand, soluble form: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3.both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
Protein Name Cd40 Ligand
Cd40-L
T-Cell Antigen Gp39
Tnf-Related Activation Protein
Trap
Tumor Necrosis Factor Ligand Superfamily Member 5
Cd Antigen Cd154 Cleaved Into - Cd40 Ligand - Membrane Form - Cd40 Ligand - Soluble Form
Scd40l
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-5668541
Reactome: R-HSA-5676594
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Cell Surface
Cd40 Ligand
Soluble Form: Secreted
Release Of Soluble Cd40l From Platelets Is Partially Regulated By Gp Iib/Iiia
Actin Polymerization
And A Matrix Metalloproteinases (Mmp) Inhibitor-Sensitive Pathway
Alternative Antibody Names Anti-Cd40 Ligand antibody
Anti-Cd40-L antibody
Anti-T-Cell Antigen Gp39 antibody
Anti-Tnf-Related Activation Protein antibody
Anti-Trap antibody
Anti-Tumor Necrosis Factor Ligand Superfamily Member 5 antibody
Anti-Cd Antigen Cd154 Cleaved Into - Cd40 Ligand - Membrane Form - Cd40 Ligand - Soluble Form antibody
Anti-Scd40l antibody
Anti-CD40LG antibody
Anti-CD40L antibody
Anti-TNFSF5 antibody
Anti-TRAP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号