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  • 产品名称：Anti-BEND3 antibody (STJA0008545)

  • 产品型号：STJA0008545
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BEND3 antibody (STJA0008545)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-BEN domain-containing protein 3 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BEND3
Gene ID: 57673
Uniprot ID: BEND3_HUMAN
Specificity: This antibody detects endogenous levels of BEND3 at Human, Mouse
Immunogen: Synthesized peptide derived from human BEND3
Post Translational Modifications Sumoylated at Lys-20 by SUMO1 and at Lys-512 by SUMO1, SUMO2 and SUMO3. Sumoylation probably occurs sequentially, with that of Lys-20 preceding that of Lys-512. It does not alter association with heterochromatin, but is required for the repression of transcription.
Function Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites. Stimulates the ERCC6L translocase and ATPase activities.
Protein Name Ben Domain-Containing Protein 3
Cellular Localisation Nucleus
Nucleolus
In The Nucleus
Observed In Heterochromatic Foci Containing Cbx1
Cbx3
Cbx5 And Histone H3 Trimethylated At 'Lys-9'
Released From Chromatin During Decondensation
Association With Heterochromatin Does Not Depend On Sumoylation
Alternative Antibody Names Anti-Ben Domain-Containing Protein 3 antibody
Anti-BEND3 antibody
Anti-KIAA1553 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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