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  • 产品名称：Human MAPRE1 (Microtubule Associated Protein RP/EB Family, Member 1) Sandwich ELISA Kit (STJE0010486)

  • 产品型号：STJE0010486
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human MAPRE1 (Microtubule Associated Protein RP/EB Family, Member 1) Sandwich ELISA Kit (STJE0010486)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.036ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This MAPRE1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: MAPRE1
Gene ID: 22919
Uniprot ID: MARE1_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Ubiquitously expressed.
Post Translational Modifications Acetylation at Lys-220 by KAT2B/PCAF promotes dynamic kinetochore-microtubule interactions in early mitosis. Crotonylated by KAT5 during mitosis, promoting astral microtubule plasticity and dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation, thereby ensuring accurate spindle positioning in mitosis. Decrotonylated by HDAC3.
Function Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2. Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation. May play a role in cell migration.
Protein Name Microtubule-Associated Protein Rp/Eb Family Member 1
Apc-Binding Protein Eb1
End-Binding Protein 1
Eb1
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-2565942
Reactome: R-HSA-380259
Reactome: R-HSA-380270
Reactome: R-HSA-380284
Reactome: R-HSA-380320
Reactome: R-HSA-5620912
Reactome: R-HSA-5663220
Reactome: R-HSA-68877
Reactome: R-HSA-8852276
Reactome: R-HSA-8854518
Reactome: R-HSA-9648025
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Golgi Apparatus
Spindle
Spindle Pole
Associated With The Microtubule Growing Distal Tips
Recruitment To The Golgi Apparatus Requires The Presence Of Pde4dip Isoform 13/Mmg8/Smyle
Alternative ELISA Names Microtubule-Associated Protein Rp/Eb Family Member 1 ELISA kit
Apc-Binding Protein Eb1 ELISA kit
End-Binding Protein 1 ELISA kit
Eb1 ELISA kit
MAPRE1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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