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  • 产品名称：Human MSN (Moesin) Sandwich ELISA Kit (STJE0010738)

  • 产品型号：STJE0010738
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human MSN (Moesin) Sandwich ELISA Kit (STJE0010738)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.064ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This MSN Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: MSN
Gene ID: 4478
Uniprot ID: MOES_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity In all tissues and cultured cells studied.
Post Translational Modifications Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. Phosphorylation on Thr-558 by STK10 negatively regulates lymphocyte migration and polarization. S-nitrosylation of Cys-117 is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) implicating the iNOS-S100A8/9 transnitrosylase complex.
Function Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs. Modulates phagolysosomal biogenesis in macrophages. Participates also in immunologic synapse formation.
Protein Name Moesin
Membrane-Organizing Extension Spike Protein
Database Links Reactome: R-HSA-437239
Reactome: R-HSA-8950505
Reactome: R-HSA-9662360
Reactome: R-HSA-9662361
Reactome: R-HSA-9725370
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasm
Cytoskeleton
Apical Cell Membrane
Cell Projection
Microvillus Membrane
Microvillus
Phosphorylated Form Is Enriched In Microvilli-Like Structures At Apical Membrane
Increased Cell Membrane Localization Of Both Phosphorylated And Non-Phosphorylated Forms Seen After Thrombin Treatment
Localizes At The Uropods Of T Lymphoblasts
Alternative ELISA Names Moesin ELISA kit
Membrane-Organizing Extension Spike Protein ELISA kit
MSN ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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