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  • 产品名称：Anti-CD300LF antibody (23-150) (STJ115771)

  • 产品型号：STJ115771
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD300LF antibody (23-150) (STJ115771)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CD300LF (23-150) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CD300LF
Gene ID: 146722
Uniprot ID: CLM1_HUMAN
Immunogen Region: 23-150
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 23-150 of human CD300LF (NP_001276011.1).
Immunogen Sequence: TQITGPTTVNGLERGSLTVQ CVYRSGWETYLKWWCRGAIW RDCKILVKTSGSEQEVKRDR VSIKDNQKNRTFTVTMEDLM KTDADTYWCGIEKTGNDLGV TVQVTIDPAPVTQEETSSSP TLTGHHLD
Tissue Specificity Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells.
Post Translational Modifications Phosphorylated on tyrosine.
Function Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition.recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.
Protein Name Cmrf35-Like Molecule 1
Clm-1
Cd300 Antigen-Like Family Member F
Immune Receptor Expressed On Myeloid Cells 1
Irem-1
Immunoglobulin Superfamily Member 13
Igsf13
Nk Inhibitory Receptor
Cd Antigen Cd300f
Database Links Reactome: R-HSA-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Cmrf35-Like Molecule 1 antibody
Anti-Clm-1 antibody
Anti-Cd300 Antigen-Like Family Member F antibody
Anti-Immune Receptor Expressed On Myeloid Cells 1 antibody
Anti-Irem-1 antibody
Anti-Immunoglobulin Superfamily Member 13 antibody
Anti-Igsf13 antibody
Anti-Nk Inhibitory Receptor antibody
Anti-Cd Antigen Cd300f antibody
Anti-CD300LF antibody
Anti-CD300F antibody
Anti-CLM1 antibody
Anti-IGSF13 antibody
Anti-IREM1 antibody
Anti-NKIR antibody
Anti-UNQ3105 antibody
Anti-PRO10111 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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